Abstract

A STUDY OF DRUG RESISTANCE OF METHICILLIN RESISTANCE STAPHYLOCOCCUS AUREUS (MRSA) IN RURAL AND URBAN TERTIARY CARE CENTERS

B. Srinivas*, B Aruna Sree , M.D., Sarita Kumari Nayak, (M.D), Bandaru Narasinga Rao, M.D., Ph.D

ABSTRACT

Purpose: Staphylococcus aureus is worldwide cause of various infections. this study attempts to (1) determine the prevalence of Methicillin Resistant Staphylococcus aureus (MRSA) in rural and urban areas and (2) their susceptibility pattern to various antimicrobial agents. Methodology: A total of 11,815 pus samples from various etiology were analysed of which 4540 from rural and 7275 from urban. Of which 607 (13.37%), 737 (10.13%) were Staphylococcus aureus in rural & urban tertiary care centers respectively, which were confirmed by various biochemical tests, cultural methods like using Mannitol salt agar and using Oxacillin discs (1μg) for Methicillin susceptibility. Results:The prevalence of MRSA in rural was 357 (58.81%)and urban was 394 (53.46%), Male and female sex distribution were 197 (55.18%), 160 (44.81%), 210 (53.30%), 184 (46.70%), in rural & urban tertiary care centers respectively. The MRSA were more sensitive to tetracycline, linezolid and vancomycin drugs. Conclusion: The present study showed MRSA were more prevalent in rural setup than urban set up. There was high resistance to penicillin, cloxacillin, erythromycin, azithromycin, amikacin, gentamicin, ciprofloxacin, gatifloxacin, cephalexine, cefuroxime, cefoperazone, piperacillin+tazo in both centers, indicating the need for developing appropriate antibiotic policy and limiting the use of powerful antibiotics in both areas.

Keywords: Methicillin resistant Staphylococcus aureus(MRSA), rural, urban, prevalence, antimicrobial susceptibility testing.