GASTRO-CYTOPROTECTIVE AND HEALING EFFECTS OF THE STEM BARKS AQUEOUS EXTRACT OF ANTHOCLEISTA SCHWEINFURTHII GILG (LOGANIACEAE) ON GASTRIC ULCERS
Christophe Mezui*, Frida Longo, Celine Nkenfou, Perfusion A. Amang, Ntsayo Fokou and Paul V. Tan
ABSTRACT
Anthocleista schweinfurthii is used in the traditional management of
gastro-duodenal ulcers; this led us to evaluate the gastro-cytoprotective
and healing effects of this plant. Anti-ulcer activity of the stem barks
aqueous extract of Anthocleista schweinfurthii (EAS) was evaluated
using five methods: HCl/ethanol; indomethacin - HCl/ethanol;
Absolute ethanol; Pylorus-ligated (acute gastric lesions), and Acetic
acid-induced chronic ulcers in rats. The parameters assessed were
mucus production; gastric ulcer index; pH, acid concentration and
volume of gastric contents. Sucralfate, cimetidine and ranitidine were
used as the reference anti-ulcer drugs. In all cases, oral administration
of EAS (250 and 500mg/kg), dose-dependently, prevented gastric
lesion formation (p<0.001). Generally, this cytoprotective action was
accompanied by significant increases in gastric mucus production.
Intraperitoneal indomethacin (30mg/kg) significantly reduced mucus production but did not
reduce the cytoprotective effect. In pylorus ligation, the extract did not reduce acidity and
volume of gastric juice compared to controls. All doses of the extract showed a highly
significant (p<0.001) reduction of ulceration with a healing rate over 90%. Present study indicates that A. schweinfurthii possesses significant anti-ulcer activity and these results are
substantiated by the histopathological examination of the ulcerated stomachs.
Keywords: Gastric, ulcer, Cytoprotection, Anthocleista schweinfurthii, Loganiaceae.
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