Abstract

“ENHANCING DISSOLUTION RATE OF NAPROXEN USING MODERN TECHNIQUES”

Dr. D Nagendrakumar, Ganesh G Keshavshetti, Shardor Ambarish, Pooja Kulkarni*

ABSTRACT

In the present study an attempt has been made to increase the in vitro dissolution rate of poorly water-soluble drug naproxen, by employing novel solid dispersion methods are one of the most promising strategies to improve the oral bioavailability of poorly water soluble drug. Naproxen formulations were prepared by using hot melt method, and solvent evaporation method using carrier like urea. The formulation were prepared with the above mentioned carriers in three different drug-carrier (w/w) ratios of 1:1, 1:3 and 1:5. The prepared solid dispersion was subjected for percentage practical yield, drug content, FTIR and DSC studies. Absence of significant drug-carrier interaction was confirmed by FTIR and DSC data. In-vitro release profiles of all solid dispersions (F-1 to F-6) were comparatively evaluated and also studied against pure naproxen. The drug release from all the solid dispersion displayed nearly zerot-order release kinetics with r values ranging from approximately 0.906 to 0.998. Solid dispersion of formulation (F6) naproxen and urea combination prepared in (1:5) ratio showed excellent solubility and the dissolution rate was found to be 91.23% was selected as the best formulation in this study. Solubility of naproxen was increased as the concentration of carriers increased. Solvent evaporation method is most efficient and reliable method for enhancing dissolution of poorly water soluble drugs as compare to hot melt method.

Keywords: Naproxen Urea Enhancement dissolution Solid dispersion, etc.