WJPPS Citation

Login

Search

News & Updation

  • Updated Version
  • WJPPS introducing updated version of OSTS (online submission and tracking system), which have dedicated control panel for both author and reviewer. Using this control panel author can submit manuscript
  • Call for Paper
    • WJPPS  Invited to submit your valuable manuscripts for Coming Issue.
  • Journal web site support Internet Explorer, Google Chrome, Mozilla Firefox, Opera, Saffari for easy download of article without any trouble.
  •  
  • New Impact Factor
  • WJPPS Impact Factor has been Increased to 8.025 for Year 2024.

  • WJPPS: MARCH ISSUE PUBLISHED
  • March Issue has been successfully launched on 1 March 2024.

  • ICV
  • WJPPS Rank with Index Copernicus Value 84.65 due to high reputation at International Level

  • Scope Indexed
  • WJPPS is indexed in Scope Database based on the recommendation of the Content Selection Committee (CSC).

Abstract

FORMULATION AND EVALUATION OF SUBLINGUAL DRUG DELIVERY SYSTEM CONTAINING ANTI-ULCERATIVE AGENT

Vijaya Kumar B S, Abdul Nasir Kurnool?, Ramchandra N. Chilkawar, S E Jagadeesha

ABSTRACT

The objective of the current study was to develop and optimize a sublingual tablet of Pantoprazole sodium which is an effective drug in the treatment of peptic ulcer such as duodenal and gastric ulcer. The tablets were prepared by direct compression method using different superdisintegrating agents such as crospovidone, sodium starch glycolate, kyrone T-314. The compatibility studies of drug and excipients were performed by FTIR spectroscopy. After examining the flow properties of the powder blends, the results are found to be within prescribed limits and indicated good flowing property, it was subjected to tablet compression. The tablets were evaluated for post compression parameters like weight variation, hardness, thickness, friability, drug content uniformity, wetting time, and in-vitro disintegration time, in vitro drug release study. An optimized tablet formulation i.e. F9 was found which provided short wetting time of 28 sec, in-vitro disintegration time of 29sec which facilitates its faster disintegration and higher the drug content of 98.99%, the best in-vitro drug release was found to be in formulation F9 i.e. 94.01% during the end of 14min. From the above results, it indicate that formulation F9 containing equal ratio of different superdisintegrating agents (1:1:1) emerged as the overall best formulation based on drug release characteristics with pH 6.8 phosphate buffer as dissolution medium. Stability studies were carried out which indicate that selected formulation (F7, F8, F9) was stable.

Keywords: Sublingual tablets, Pantoprazole sodium, peptic ulcer, crospovidone, sodium starch glycolate, kyrone T-314, direct compression.


[Download Article]     [Download Certifiate]

Call for Paper

World Journal of Pharmacy and Pharmaceutical Sciences (WJPPS)
Read More

Online Submission

World Journal of Pharmacy and Pharmaceutical Sciences (WJPPS)
Read More

Email & SMS Alert

World Journal of Pharmacy and Pharmaceutical Sciences (WJPPS)
Read More