Abstract

HYPOLIPIDEMIC AND ANTIOXIDANT ACTIVITY OF PHOENIX DACTYLIFERA L. IN ALBINO WISTAR RATS

I.Pushpa and Dr. J. Jayachitra*

ABSTRACT

Objective: To investigate the hypolipidemic and antioxidant activity of phoenix dactylifera L. in albino wistar rats. Methods: Rats were divided into four groups, groups 1 received water and 5% carboxymethyl cellulose (CMC); groups 2 received control and ethanolic extract phoenix dactylifera groups 3 received triton WR1339 with 5% carboxymethyl cellulose (CMC) ;and group 4 received triton WR1339 with 5% carboxymethyl cellulose (CMC) and ethanolic extract phoenix dactylifera for the total experimental period of 8 days. Results: The results showed significantly elevated levels of serum thiobarbituric acid reactive substances (TBARS), total cholesterol, triglycerides, VLDL, LDL and significantly lowered enzymic antioxidant activity of superoxide dismutase(SOD) and HDL in triton WR1339 treated rats compared with the control. Ethanolic extract phoenix dactylifera administration to rats with triton WR1339 induced hyper lipidemia significantly decreased the levels of thiobarbituric acid reactive substances, total cholesterol, triglycerides, VLDL, LDL and significantly elevated the activity of superoxide dismutase and HDL in the serum compared with those of the unsupplemented triton WR1339 treated rats. The different biochemical parameters registered a significant rise in serum of triton WR 1339 treated rats as compared to the normal control. Conclusion: These findings suggest that the hypolipidemic and antioxidant activity of phoenix dactylifera L. in albino wistar rats.

Keywords: Phoenix dactylifera (L); hypolipidemic and antioxidant activity; triton WR 1339.