Abstract

DESIGN AND CHARACTERIZATION OF DISPERSIBLE TABLET OF FEXOFENADINE HCl

*Renuka Sangondi Giriyappa, Ramchandra N. Chilkawar, Dr. G. Y. Narmada Narendra C., K.S.Mallikarjun, Dr. Basavaraj. K. Nanjwade

ABSTRACT

The objective of the work was to Design and evaluate the Dispersible drug delivery system containing Fexofenadine HCl (FEX) as a model drug. FEX tablets were prepared by direct compression and wet granulation method incorporating Crospovidone, cross caramellose sodium, Doshion-Ds, Doshion-D as disintegrants. MCC and lactose were used as diluents, magnesium stearate and talc used as lubricant and glidant. Aspartame as sweetening agent, vanilla as flavoring agent, Erythrosine supra as coloring agent, Aerosil, Pregelatinised starch as suspending and binding agent respectively. Dissolution profiles were studied in 0.1N HCl medium. Tablets were also evaluated for standards of dispersible tablets and were compared with marketed products. The optimized formulation was checked for stability at 30ºC, 65% RH and 40ºC, 75% RH which was found to be stable. The drug release profile of the both formulations was well released within 30 minutes and uniform drug release as compared with marketed formulation.

Keywords: Fexofenadine (FEX), Disintegrants, Drug release, Dissolution profile.