Abstract

COCCINIA GRANDIS LEAVES EXTRACTS AMEOLARATES ALLOXAN INDUCED DIABETIC IN RATS

Kavitha.A*, K. Sasi Kala, Krishna Reddy.B, Venkata Rao.Vutla, Narendra Babu.A

ABSTRACT

Background: Coccinia grandis is used in India and other parts of the world as a medicinal plant. Aim and Objective: The plant is being evaluated for anti diabetic potential because diabetes mellitus has assumed a worldwide dimension and plant with safe potential are being deployed as they are available all year round and are cheap for use by the rural populace. Materials and Methods: The anti diabetic effect of the ethanol extract of Coccinia grandis was evaluated in wister rats. Standard Phytochemical methods were used to test for the presence of photoactive compounds in the plant the anti-diabetic activities of the ethanolic extract of the plant were assessed using standard. Diabetes mellitus was induced in rats using Alloxan (150mg/kg) while glibenclamide at 10mg/kg was the reference drug used in this study. Results: The ethanolic leaf extract at 250 mg/kg body weight caused a significant reduction on the glucose level of diabetic rats. And the P value <0.05. Conclusion: This study may have validated the traditional basis for the use of Coccinia grandis an anti diabetic agent.

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