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Abstract

EXTENDED RELEASE FORMULATION OF BCS CLASS I DRUGS

Prof Dipti Phadtare*, Ganesh Phadtare, Nilesh Barhate and Prof Dr Ashawat Mahendra singh

ABSTRACT

The aim of extended release formulation is to increase the bioavailability, as it is important in the optimization of the drug development. BCS is a valuable tool in pharmaceutical science. Formulation scientist can optimize the drug development by applying the prediction of solubility & permeability which have influence on the dissolution profile of a drug product & ultimately on Bioavailability & Bioequivalence. In the present review the role of Biopharmaceutics classification system (BCS) is given in the extended release drug delivery system of BCS class I drugs. Mathematical models enable the quantitative analysis of drug release kinetics which reduces time during drug formulation & serves as important tool in product development & optimization.

Keywords: Biopharmaceutics classification system, Bioavailability, Bioequivelence, solubility, Permeability, extended release.


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