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World Journal of Pharmacy and
Pharmaceutical Sciences

( An ISO 9001:2015 Certified International Journal )

An International Peer Reviewed Journal for Pharmaceutical and Medical Research and Technology

Impact Factor : 8.025

ICV : 84.65

WJPPS Citation

	All	Since 2019
Citation	5450	3969
h-index	23	20
i10-index	134	84

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WJPPS introducing updated version of OSTS (online submission and tracking system), which have dedicated control panel for both author and reviewer. Using this control panel author can submit manuscript

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New Impact Factor

WJPPS Impact Factor has been Increased to 8.025 for Year 2024.

WJPPS Rank with Index Copernicus Value 84.65 due to high reputation at International Level

Scope Indexed

WJPPS is indexed in Scope Database based on the recommendation of the Content Selection Committee (CSC).

WJPPS: APRIL ISSUE PUBLISHED

April Issue has been successfully launched on 1 April 2024.

Abstract

FORMULATION AND EVALUATION OF LEVETIRACETAM EXTENDED RELEASE TABLETS

Airaj Mahajabeen*, Dr. E.Hari Krishna and Ramya Sri Sura

ABSTRACT

The aim of the present study was to develop an extended release formulation of Levetiracetam to maintain constant therapeutic levels of the drug for over 12 hrs. Various grades of polymethacrylate polymers and ethyl cellulose were employed as polymers. Levetiracetam dose was fixed as 500 mg. Total weight of the tablet was considered as 900 mg. Polymers were used in different concentrations. All the formulations passed various physicochemical evaluation parameters and they were found to be within limits. Whereas from the dissolution studies it was evident that the formulation (F6) showed better and desired drug release pattern i.e.,98.34 % in 12 hours. It followed zero order release kinetics mechanism.

Keywords: Levetiracetam, Eudragit RL 100, Eudragit Rs 100, Ethyl cellulose, Extended release tablets.

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