Abstract

IN-VITRO ALPHA AMYLASE AND ALPHA GLUCOSIDASE INHIBITORY ACTIVITY OF VARIOUS SOLVENT EXTRACTS OF HYBANTHUS ENNEASPERMUS LINN.

Vennila V.* and Pavithra V.

ABSTRACT

Objective: The objective of the present study was to evaluate the inhibitory activity of alpha-amylase and alpha-glucosidase activity of various extracts of Hybanthus enneaspermus. Methods: The whole plant of H. enneaspermus was dried under shade and powdered. The powdered material was used for the preparing the various solvent extracts, which were used for the invitro antidiabetic study. Results: Various extracts of H. enneaspermus showed alpha-amylase and alpha-glucosidase inhibitory effect in a concentration-dependent manner. Ethanolic extract possessed great inhibitory activity compared with other extracts. Conclusion: The present study confirms the evidence of hypoglycemic effect of H. enneaspermus through enzyme inhibitory activity and gives a clear evidence that H. enneaspermus has antidiabetic activity.

Keywords: alpha-glucosidase activity, Hybanthus enneaspermus, Ethanolic.