Abstract

SYNTHESIS, STRUCTURAL AND ANTIMICROBIAL STUDIES OF SOME NEW TIN (II) COMPLEXES WITH SEMICARBAZONES AND THIOSEMICARBAZONES.

Neha, Kavita Yadav, Sarita Varshney and Anil K. Varshney*

ABSTRACT

Semicarbazone and thiosemicarbazone ligands used in these studies were prepared by condensing acetyl acetone, benzoyl acetone and glyoxal with semicarbazide hydrochloride and thiosemicarbazide in 1:2 molar ratio in ethanolic medium.These ligands were used to synthesize a series of new metal complexes of Sn (II) in 1:1 molar ratio using dry tetrahydrofuran(THF) as a reaction medium. Purity of complexes has been confirmed by thin layer chromatography. Characterization and structure elucidation of these tin (II) complexes have been investigated on the basis of elemental analysis, molar conductance and UV, IR, (1H, 13C, 119Sn) NMR spectral studies. The ligands and their metal complexes have been screened for antibacterial and antifungal activities and are found quite active in this respect. Tin (II) complexes have been found to be more active than their uncomplexed ligands.

Keywords: Semicarbazone, Thiosemicarbazone, Spectral studies, Antibacterial activities, Antifungal activities, Tin (II) complexes.