Abstract

EVALUATION OF MONO SODIUM GLUTAMATE INDUCED NEPHROTOXICITY IN ADULT WISTAR ALBINO RATS

Sandharbh Kumar*, Nitesh Kumar, Bhoopendra Kumar

ABSTRACT

The main significance of this research is to investigate the effect mono sodium glutamate (MSG) on the kidney of Wistar albino rats on a daily intake for a different time interval. Forty Wistar albino rats of body weight 200 ± 30 gm (6-7 month old) were used in the present study. Animals were divided into four groups of five male and five females i.e. one control and three treatment groups. Group I served as a control and received normal distilled water while group II, III and IV received MSG at the dose level of 70 mg/100 gm of body weight daily for a period of 30 days, 45 days and 60 days. Decreased in body weight observed in that group of animals who received MSG at the dose level of 70 mg/100 gm of body weight for a period of 60 days. However, decrease in Haemoglobin, PCV and Neutrophill was also observed in group III and group IV (MSG at the dose level of 70 mg/100 gm of body weight for a period of 45 days and 60 day). The value of RBC was also decreased in the group IV (MSG at the dose level of 70 mg/100 gm of body weight for a period of 60 days). However the value of WBC was significantly increased in the animal of group III and group IV. In the biochemical parameters, the value of SGPT and SGOT was significantly increased in the group III and group IV (MSG at the dose level of 70 mg/100 gm of body weight for a period of 45 and 60 days). BUN and Creatinine were significantly increased in the group IV animals. Kidney histopathology showed some pathological changes in renal glomerulus and renal convoluted tubules, swelling in lining endothelium of the glomeruli, loss of brush borders of proximal convoluted tubules as well as necrotic lesions. The study suggests that continuous consumption of MSG dosage range tested herein may result in varying degrees of kidney injury, depending on the concentration administered.

Keywords: Nephrotoxicity, Monosodium Glutamate.