Abstract

BACTERIAL THERAPY: A NOVEL APPROACH FOR CANCER TREATMENT

Priyanka A. Mohite*, Dhanashree H. Surve, Manisha Karpe, Dr.Vilasrao Kadam

ABSTRACT

In the wake of growing global burden of cancer, newer cancer prevention and control modalities are being explored. One such novel experimental strategy is the implication of natural and genetically modified non-pathogenic bacterial species as potential antitumor agents. The first scientifically observed treatment dates back to the Nineteenth century, when bacteria were not even known to cause disease. The use of live, attenuated or genetically-modified, non-pathogenic bacteria has begun to emerge as potential antitumor agents, either to provide direct tumoricidal effects or to deliver tumoricidal molecules. Bacteria also use as vector to delivering either tumoricidal agents or prodrug converting enzyme. Bacterial toxins are alsoshowing anticancer activity, bacterial toxins along with antibody gives immunotoxins. Bacterial spores are also use in the treatment. Although bacteria showing promising results but there are some limitation using bacteria as anticancer agent.

Keywords: Bacteria, prodrug, tumoricidal agents, immunotoxins, cancer.