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Abstract

INVESTIGATION ON ARISTOLOCHIA INDICA - IMMUNOMODULATOR ACTIVITY

G.K.Mallaiah*, K. Thirupathi and G. Krishna Mohan

ABSTRACT

The immunomodulator activity of Aristolochia indica was carried out in mice and rats. The assessment of immunomodulatory activity was carried out by various hematological and serological tests. In this study, various doses (100, 200 and 400mg/kg body weight/day) of the methanolic extract and its bioactive fractions of the roots of the plant were administered in mice and rats. Of these, Ethyl acetate fraction showed significant activity and increased phagocytic response, both cellular and humoral antibody response. The activity reported was dose dependent and test extract posses promising immuno-stimulant properties.

Keywords: Aristolochia indica, rats, mice, hematological and serological tests.


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