WJPPS Citation

Login

Search

News & Updation

  • Updated Version
  • WJPPS introducing updated version of OSTS (online submission and tracking system), which have dedicated control panel for both author and reviewer. Using this control panel author can submit manuscript
  • Call for Paper
    • WJPPS  Invited to submit your valuable manuscripts for Coming Issue.
  • Journal web site support Internet Explorer, Google Chrome, Mozilla Firefox, Opera, Saffari for easy download of article without any trouble.
  •  
  • New Impact Factor
  • WJPPS Impact Factor has been Increased to 8.025 for Year 2024.

  • WJPPS: MARCH ISSUE PUBLISHED
  • March Issue has been successfully launched on 1 March 2024.

  • ICV
  • WJPPS Rank with Index Copernicus Value 84.65 due to high reputation at International Level

  • Scope Indexed
  • WJPPS is indexed in Scope Database based on the recommendation of the Content Selection Committee (CSC).

Abstract

FORMULATION & EVALUATION OF FLOATING TABLET OF VENLAFAXINE

Kundan Singh Sengar*, A K Pathak and Mukul Tailang

ABSTRACT

The study aimed for Formulation development of floating tablet of venlafaxine Hydrochloride. Floating tablets is new era for successful development of controlled release formulation along with various features to provide successful drug delivery system. The purpose of the present investigation is to formulate floating tablets of Venlafaxine HCl, a novel antidepressant by direct compression technique using microcrystalline cellulose, HPMC, Sodiumbicarbonate. The drug-excipients interaction was ruled out through FTIR studies. The prepared batches were evaluated for organoleptic properties, hardness, friability, weight variation, parameters, buoyancy time, floating lag time and in- vitro dissolution study and stability. The drug content of all the formulations was within the acceptable limits of the British Pharmacopoeia. The release profile and drug content were remained unchanged after 1 month storage of tablets at 40 ± 2oC and 75 ± 5% RH. In vitro dissolution study was carried out in pH 1.2 buffer. The in vitro drug release of optimised formulation followed Higuchi kinetics and the drug release mechanism was found to be non-fickian type.

Keywords: Venlafaxine hydrochloride; Direct compression; floating tablet; Stability studies.


[Download Article]     [Download Certifiate]

Call for Paper

World Journal of Pharmacy and Pharmaceutical Sciences (WJPPS)
Read More

Online Submission

World Journal of Pharmacy and Pharmaceutical Sciences (WJPPS)
Read More

Email & SMS Alert

World Journal of Pharmacy and Pharmaceutical Sciences (WJPPS)
Read More