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Abstract

EVALUATION OF LIPOPROTEIN A AND LIPID TETRAD INDEX PATTERN IN DIABETIC PATIENTS ATTENDING METABOLIC CLINIC IN THE FEDERAL MEDICAL CENTRE, OWERRI, IMO STATE

Nwosu,D.C.,Nwanjo,H.U.,Obeagu, Emmanuel Ifeanyi*, Ugwu, G.U., Ofor,I.B.,Okeke,A.,Ochei,K.C.,Kanu,Stella Ngozika, Okpara,K.E.,

ABSTRACT

Lipoprotein A levels and Lipid Tetrad Index pattern were evaluated in diabetes mellitus patients attending metabolic clinic in the Federal Medical Centre, Owerri, Imo State. Two hundred (200) subjects (120 diabetics (tests) and 80 non diabetic, (controls) were recruited for the study, all in the age group of 20 to 60 years. Samples were analysed using appropriate analytical methods and the statistical analysis was performed on Statistical Package for Social Science (SPSS) Windows version 20.0. Test of significance was determined using the student's t-test and the statistical significance was set at p<0.05. The results were expressed as Mean ± SD. The study showed a statistically significant (p<0.05) increase in lipoprotein A (mmol/L), and lipid tetrad index thus: (0.27±0.03; and 1.79±0.82) in the tests compared to the controls (0.17±0.03; and 0.49±0.24) respectively. This present study therefore, concluded that lipoprotein A [Lp (a)] levels, and lipid tetrad index play key roles, and serve as a predictive index in the development of coronary artery disease, in diabetes mellitus, and that gender (sex) and age (years) had no effect on the assayed parameters. The routine evaluation of lipoprotein A in the management of diabetes mellitus is therefore recommended.

Keywords: Lipoprotein A, Lipid tetrad index and Diabetic patients.


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