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Abstract

DOCETAXEL-INDUCED CHANGES IN CHOLESTEROL PROFILE: PROTECTIVE ROLE OF NARINGENIN AND NARINGIN

Dr. Supratim Ray*

ABSTRACT

The study was designed with an aim to evaluate the protective effects of naringenin and naringin on docetaxel-induced changes in cholesterol profile in vitro. Goat blood was used as lipid source for the model. In the cholesterol profile total cholesterol (TC) and high density lipoprotein (HDL) cholesterol content of goat blood was determined. The study reveals that docetaxel has the induction capacity to produce changes in cholesterol profile. It was also noticed that naringenin / naringin had the capacity to inhibit docetaxel-induced changes in cholesterol profile. Interpretation of the results is supported by analysis of variance and also by statistical multiple comparison analysis using least significant different procedure.

Keywords: Docetaxel, Naringenin, Naringin, Total cholesterol, HDL.


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