Abstract

IN VITRO AND IN VIVO ANTIDIABETIC ACTIVITY OF METHANOL EXTRACT OF TERMINALIA CATAPPA LINN BARK IN STZ INDUCED DIABETIC RATS

Lakshminarasimhaiah* and Pradeep Goyal

ABSTRACT

The bark of Terminalai catappa was collected, authenticated, dried, powdered and extracted with petroleum ether, chloroform, ethylacetate and methanol. In vitro antidiabetic activity was conducted for extracts of Terminalia catappa. The methanol extract was found to be active after the results were compared with acarbose. In vivo antidiabetic activity was conducted for methanol extract, controle and standard on STZ induced diabetic rats. Measurement of blood glucose and biochemical parameters were conducted. The methanol extract shown significant antidiabetic activity at dose levels 1/5 of lethal dose. Histological studies of pancreas of rats were done. The results were compared with glibenclamide. Methanolic extract of Terminalia catappa bark exhibited significant antidiabetic activity in streptozotocin induced diabetic rats. This extract showed improvement in parameters like body weight and lipid profile as well as regeneration of β-cells of pancreas. Hence, it has value in treatment of diabetes.

Keywords: Antidiabetic activity, Terminalia catappa, STZ, Extraction, Insulin.