Abstract

FORMULATION METHODS OF ORAL DRUG DELIVERY TO ENHANCE BIOAVAILABILITY OF BCS CLASS 4 DRUGS: A REVIEW

*Pande S. V., Biyani K. R.

Anuradha College of Pharmacy, Chikhali, India.

ABSTRACT

Oral delivery is the most preferred route of drug administration due to convenience, possibility of self-administration and improved patient compliance hence nowadays many of the generic drug companies are preferred to produce bioequivalent oral drug products. Bioavailability is defined as the rate and extent of absorption of unchanged drug from its dosage form. It is one of the most important parameter to achieve desired concentration of drug in systemic circulation for pharmacological response to be shown. Factors that influence oral bioavailability are (1) Drug properties and (2) the physiology of the gastrointestinal tract (3) patient related factors. The Biopharmaceutics Classification System classifies drugs into four groups Class 1: high permeability, high solubility; Class 2: high permeability, low solubility; Class 3: low permeability, high solubility; and Class 4: low permeability, low solubility. This review is intended to discuss the various traditional and novel techniques for bioavailability enhancement of BCS Class IV drugs for oral pharmaceutical formulation with combination or individual development of techniques like Nano Emulsion Technique, Cyclodextrin Inclusion Complexation, Spray freeze dying, Use of Chitosan derivative, Use of Saponins, Use Straight chain fatty acids, pH adjustment technique, Self-emulsifying drug delivery systems, Micro Encapsulation technique, Liposomes, etc.

Keywords: Formulation of BCS Class 4 Drugs, Bioavailability Enhancement, Oral Drug Delivery.