Abstract

ANTIDIABETIC AND ANTIHYPERLIPIDEMIC EFFECT OF BORASSUS FLABELLIFER IN STREPTOZOTOCIN (STZ) INDUCED DIABETIC RATS.

Pradeep Goyal*, Anil Kumar Agarwal, Lakashminarasimhaiah and G.K.Singh

ABSTRACT

Borassus flabellifer is used extensively in the indigenous system of medicine as an anti-diabetic agent. The current investigation focus on the antihyperglycemic and antihyperlipidemic property of acetone insoluble ethanolic fraction of Borassus flabellifer extract on streptozotocin induced diabetic rats. The diabetes induced animals were fed with inflorescence extracts of Borassus flabellifer at the increasing doses of 150mg, 300mg and 600mg of body weight. The extracts at dose of 600mg/kg body weight administrated animals revealed a significant (P<0.01) decrease blood glucose level and higher reduction in hyperlipidemia when compared to the diabetic control rats (P<0.01). The histological studies of the endocrine region of pancreas of diabetic animals revealed that shrinkage of β cells of islets of langerhans. The extracts treated animals revealed restoration of β-cells. The restoration of β cells was evident at higher dose level i.e.600mg/kg body weight extracts fed groups.

Keywords: Borassus flabellifer, streptozotocin (STZ), hyperglycemia, hyperlipidemia.