Abstract

DISPOSITION KINETICS OF CEFQUINOME IN HEALTHY RABBITS FOLLOWING INTRAMUSCULAR AND ORAL ADMINISTRATION

Shalaby, M.A.*; Goudah A.; Gihan M. Kamel and Hassan A. Shaheen

ABSTRACT

The target of the present study was to investigate the serum disposition kinetics of cefquinome, a fourth generation cephalosporin, in healthy rabbits (n = 8) following a single intramuscular (IM) injection and single oral (PO) administration at a dose rate of 10 mg/kg b.wt, using a parallel design single dose study. Blood samples were collected at appropriate times during 24 hrs administration interval. Serum samples were analyzed using High Performance Liquid Chromatography-tandem mass spectrometry (HPLC-MS/MS) method. The serum cefquinome disposition kinetic was best fitted to a two-compartment open model after IM and PO dosage. Following intramuscular and oral administration, the major pharmacokinetic
parameters (mean ± SD), elimination half-lives (t1⁄2el) were 2.60 ± 0.04 and 2.32 ± 0.06 hrs, respectively. Values of area under the curve (AUC) were 43.26± 0.69 and 34.69 ± 1.03 g.h/ml, respectively. Mean residence times (MRT) were 4.12 ± 0.05 and 3.72 ± 0.07 h, respectively. Peaks of cefquinome concentrations (Cmax) were 9.05 ± 0.06 and 8.12 ± 0.11 μg/ml attained at 0.95 ± 0.04 and 1.01 ± 0.08 h (Tmax), respectively. In conclusion the pharmacokinetic profile of cefquinome administered to rabbits by intramuscular and oral routes demonstrate good absorption and long elimination half-life.

Keywords: Cefquinome; Rabbits; Disposition kinetics; Intramuscular; Oral.