WJPPS Citation

Login

Search

News & Updation

  • Updated Version
  • WJPPS introducing updated version of OSTS (online submission and tracking system), which have dedicated control panel for both author and reviewer. Using this control panel author can submit manuscript
  • Call for Paper
    • WJPPS  Invited to submit your valuable manuscripts for Coming Issue.
  • Journal web site support Internet Explorer, Google Chrome, Mozilla Firefox, Opera, Saffari for easy download of article without any trouble.
  •  
  • New Impact Factor
  • WJPPS Impact Factor has been Increased to 8.025 for Year 2024.

  • WJPPS: MARCH ISSUE PUBLISHED
  • March Issue has been successfully launched on 1 March 2024.

  • ICV
  • WJPPS Rank with Index Copernicus Value 84.65 due to high reputation at International Level

  • Scope Indexed
  • WJPPS is indexed in Scope Database based on the recommendation of the Content Selection Committee (CSC).

Abstract

L-ARGININE PREVENTS ENDOTHELIAL DYSFUNCTION AND RESTORES TETRAHYDROBIOPTERIN LEVEL IN EXPERIMENTAL DIABETES

Ehsan Badawy, Dina Abo El-Matty, Hanaa Wafaay, Hoda Megahed, Omnia Aly and Jihan Hussein*

ABSTRACT

L-arginine is the precursor of nitric oxide (NO), the most important factor responsible for diabetes associated cardiovascular complications. In this study, we explored whether L-argenine supplementation is able to stabilize tetrahydrobiopterin (BH4) during experimental diabetes, and we also investigated how critical the elevation of BH4 and total biopterin in affecting the endothelial dysfunction. Seventy five male albino rats weighting 180-200 g were divided into five groups; control, L-arginine, diabetic, treated and prophylactic groups. After the experimental period, fasting blood samples were collected from all groups for determination of fasting blood glucose, insulin and NO. Total biopterin, and BH4 were determined by HPLC; separation was achieved on reversed phase column (250 mm x 5 μm). Column temperature was 50 °C, the excitation and emission wavelengths were 360 and 440 nm respectively. The results showed a reduction in total biopterin, and BH4 in diabetic group, although, L-arginine significantly attenuated this reduction. In conclusion, oral administration of L-arginine markedly increased BH4 availability and NO. L-Arginine may be a novel nutrient, which has important implications for the prevention and treatment of diabetes mellitus.

Keywords: biopterin, tetrahydrobiopterin, endothelial dysfunction, L-arginine, HPLC.


[Download Article]     [Download Certifiate]

Call for Paper

World Journal of Pharmacy and Pharmaceutical Sciences (WJPPS)
Read More

Online Submission

World Journal of Pharmacy and Pharmaceutical Sciences (WJPPS)
Read More

Email & SMS Alert

World Journal of Pharmacy and Pharmaceutical Sciences (WJPPS)
Read More