Abstract

IN-VIVO EVALUATION OF VARIATION IN HUMAN SKIN MOISTURE CONTENT AND TRANS EPIDERMAL WATER LOSS (TEWL) OF TOPICAL EMULSION CONTAINING CUMINUM CYMINUM (L.) SEED EXTRACT.

Muhammad Sohail*, Asrar Muhammad, Abdul Hameed, Fakhra Batool, M. Sajid ur Rehman, Fahad Mahmood

ABSTRACT

Background: Dry skin disorders are growing now a days. Various types of topical formulations are available for the treatment but are expensive and carry risks of side effects. Objective: To evaluate the moisturizing and trans epidermal water loss reducing effects of topical emulsion as cream containing botanical seed extract of Cuminum cyminum which will be cost effective for the treatment of dry skin disorders. Methods: Formulations were prepared as control and experimental and applied to 11 human volunteers. Skin Moisture content and TEWL were measured and analyzed statistically, for a duration of 8 weeks. Results: With the help of ANOVA test it was found that there is significant increase in hydration level of the skin with both the formulations i.e. control and experimental by an increase in moisture content and a decrease in TEWL while this effect is more in case of experimental formulation. Conclusion: Results of the study shows that 4% Cuminum cyminum cream is cost effective and can be used in dry skin diseases. It will be the future horizon of this research.

Keywords: Trans epidermal water loss (TEWL), Moisture content of skin, Cream of Cuminum cyminum, Dry skin