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Abstract

GC-MS ANALYSIS AND "IN VITRO" ANTICANCER ACTIVITY OF METHANOLIC ROOT EXTRACT OF ASYSTASIA GANGETICA (L.) T.ANDERSON

Tamilselvan V.* Rajeswari M. and Velayutham P

ABSTRACT

The present study has been carried out to evaluate the phytochemical constituents and "in vitro" anticancer potency of methanolic extract of Asystasia gangetica (Acanthaceae). Phytochemical studies were done by using Gas Chromatography- Mass Spectrometry analysis. In vitro anticancer activity was evaluated with MTT standard colorimetric assay against A549 human lung cell lines. Numerous novel anticancerous compounds including quercetin, isoquinoline, palladium, lucenin, cervinomycin, ungeremine etc., have been identified from the root extract paving way to do anticancer assay. "In vitro" MTT assay of the root extract showed strong anti-proliferative effect with IC50 value of 106.2µg/ml to A549 human lung cell lines. The cytotoxic effect was found to be concentration dependent. Increased concentration of the root extract showed increased cytotoxicity.

Keywords: Asystasia gangetica, GC-MS, MTT Assay, A549 Human Lung Cell Line.


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