Abstract

AN OVERVIEW OF BIOLOGICAL IMPORTANCE OF PYRIMIDINES

Rakesh Singh*, Dr. Anuja Chouhan

ABSTRACT

Pyrimidine nucleus is one of the most important heterocycles exhibiting remarkable pharmacological activities.. Pyrimidine is a heterocyclic aromatic organic compound containing two nitrogen atoms at positions 1 and 3 of the six-membered ring which shows wide range of biological activities. Numerous methods for the synthesis of pyrimidine and also their diverse reactions offer enormous scope in the field of medicinal chemistry. Condensed pyrimidine derivatives have been reported as anti-microbial, analgesic, anti-viral, antiinflammatory, anti- HIV, anti-tubercular, anti-tumor, anti-neoplastic, anti-malaria, diuretic, cardiovascular agents and hypnotic drugs for the nervous system, calcium-sensing receptor antagonists and also for antagonists of the human A2A adenosine receptor. etc. The present review provides a broad view of the biological and medicinal activity possessed by compounds having pyrimidine nucleus.

Keywords: Pyrimidine, biological activities, antimicrobial, anticancer, anti-inflammatory etc.