Abstract

LIQUISOLID TECHNIQUE: AN APPROACH FOR ENHANCEMENT OF SOLUBILITY

P. B. Dalvi* and P. R. Ingale

ABSTRACT

The “Liquisolid” technique is a novel and capable addition towards such an aims for solubility enhancement and dissolution improvement, thereby it increases the bioavailability. It contains liquid medications in powdered form. This technique is an efficient method for formulating water insoluble and water soluble drugs. This technique is based upon the admixture of drug loaded solutions with appropriate carrier and coating materials. The use of non-volatile solvent causes improved wettability and ensures molecular dispersion of drug in the formulation and leads to enhance solubility. By using hydrophobic carriers (nonvolatile solvents) one can modify release (sustained release) of drugs by this technique. Both immediate and sustained release of drug can also be achieved with the help of liquisolid technique. By using this technique, solubility and dissolution rate can be improved, sustained drug delivery systems be developed for the water soluble drugs.

Keywords: Liquisolids, carriers, coating materials, water in-soluble/ soluble drugs.