Abstract

SYNTHESIS OF NOVEL 1-(2,4'-DIFLUOROPHENYL)-3-(4"-ARYL)-2-PROPEN-1-ONES AND THEI

CH.M.M.Prasada Rao*, Rehaman S.A, Rajendra Prasad Yejella

ABSTRACT

Chalcones are important starting materials for the synthesis of various classes of five, six and seven member heterocyclic compounds. Most of these compounds are highly bioactive and are widely used in pharmaceuticals. They belongs to an important class of flavonoids, Chalcones are synthesized by Claisen–Schmidt condensation, which involves cross aldol condensation of appropriate aldehydes and ketones by base or acid catalysed reactions followed by dehydration. 12 new Chalcones were synthesized. The structures of newly synthesized compounds were confirmed by spectral evidence. Prepared compounds were tested for anti microbial activity and cytotoxicity studies.

Keywords: Chalcones, Antimicrobial Activity, antifungal activity and cytotoxicity.