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Abstract

EFFECT OF VARIOUS SUPERDISINTEGRANTS ON THE DRUG RELEASE OF TRAMADOL HYDROCHLORIDE

Padmasree Vovaldas, *Praveen Kumar Reddy. Thumma, NutanDeepthi.Ponnada
Ashok Kumar. Appapurapu, Praveen Kumar Madatha and David Banji

ABSTRACT

Formulation of a convenient dosage form for oral administration, by considering swallowing difficulty especially in case of geriatric and pediatric patient leads to poor patient compliance. To troubleshoot such problems a new dosage form known as orally disintegrating tablet has been developed. The purpose of this research work was to prepare Tramadol hydrochloride Orally Disintegrating Tablets for achievement of quicker onset of action. Tramadol is an analgesic drug which is effective for intense and moderately intense pain. In this present work an attempt has been made to know the effect of various superdisintegrants on the drug release. The various superdisintegrants such as crospovidone, croscarmellose sodium, and sodium starch glycolate were used to minimize the disintegration time. The tablet blends were prepared by using superdisintegrants in the concentrations of 5%, 6%, 7% were evaluated for various pre compression parameters. Various batches of orally disintegrating tablets were prepared by direct compression method and sublimation method. The formulated batches were evaluated for weight variation, hardness, friability, drug content, disintegration time, wetting time, water absorption ratio, in vitro dispersion time and in vitro dissolution profile and found to be in the prescribed limit. Upon comparison of two methods, sublimation method was found to be best than direct compression method. Among the formulations, tablets containing crospovidone shows least disintegration time. The drug release from orally disintegrating tablets increased with increasing concentration of superdisintegrants and was found to be highest with formulations containing crospovidone.

Keywords: Orally disintegrating tablet; Tramadol hydrochloride; Direct compression; Sublimation method; Disintegration time; In vitro drug release.


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