FORMULATION AND EVALUATION OF TASTE MASKED CACHETS OF IBUPROFEN
G. Gnanarajan*, Guno Sindhu Chakraborthy
ABSTRACT
The Ibuprofen is bitter in taste and is omitted by mostly children. Therefore an attempt has been made to prepare ester prodrug using ethyl alcohol and butyl alcohol and its bitter taste is masked by using β-cyclodextrin. The prepared prodrug is characterized by melting point, UV and IR spectroscopy. We also prepared Cachets of Ibuprofen using β- cyclodextrin as taste masking agent. Sodium carboxy methyl cellulose used as suspending agent, citric acid monohydrate used as pH modifiers. The prepared cachets bitter taste intensity was evaluated using volunteers by comparison of test samples with standard solution containing quinine at various concentrations.
Keywords: Ibuprofen, Ester Prodrug, Taste masking.
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