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Abstract

SYNTHESIS, CHARACTERIZATION, ANALGESIC, ANTIINFLAMMATORY AND ANTIMICROBIAL ACTIVITY OF NEW 7-AZAINDOLE DERIVATIVES

K.Meenakshi*, N.Gopal, M.Sarangapani, T.Anusha

ABSTRACT

In the present study, the new 1-Benzyl-7- azaindole-3-carbinol was synthesized from 1-benzyl 7-azaindole-3-aldehyde by reduction with sodium borohydride in ethanol. The formyl derivative was synthesized from 1-benzyl -7-azaindole by treating with phosphorous oxy chloride and dimethyl formamide. Benzylation of 7-azaindole produced 1-benzyl-7azaindole. Chemical structures of all the synthesized new compounds were characterized by Mass, 1HNMR, IR spectral analysis. All the synthesized compounds were evaluated for analgesic, anti-inflammatory and antimicrobial activities.

Keywords: 7-azaindole, analgesic, anti-inflammatory, antimicrobial.


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