Abstract

NEUROPROTECTIVE EFFECT OF ETHANOLIC EXTRACT OF MIMOSA PUDICA IN D-GALACTOSE INDUCED ALZHEIMER’S MODEL

Sibi P.Ittiyavirah* and Ibrahim Pullachol

ABSTRACT

Objective: The objective of the present study was to evaluate the possible neuroprotective effect of ethanolic extract of Mimosa pudica (EEMP) in chronic Alzheimer’s model using albino wistar rats. Methods: The dried whole part of the plant were subjected to hot continuous extraction method using ethanol as solvent and were subjected for phytochemical analysis.1 The parameters employed for assessing nootropic activity were transfer latency, retention latency and number of memory errors in elevated plus maze, Morris water maze and radial arm maze. These activities were tested at oral dose of extract 500 mg/kg, piracetam 50 mg/kg was used for comparison and D-galactose 100mg/kg was used as control group. Results: Phytochemical screening confirmed the presence of flavonoids, phenolic compounds and steroids. EEMP treatment had shown a significant protective effect in memory dysfunction caused by D- Galactose in various model. Conclusion: It is concluded that ethanolic extract of M. pudica possessed significant neuroprotective effect against D-Galactose induced Alzheimer’s model.

Keywords: Alzheimers disease, D-Galactose, EEMP.