Abstract

VIROSOME – DRUG AND VACCINE DELIVERY SYSTEM

Mr. Bhamare Gaurav, Mrs. Karpe Manisha, Dr. Kadam Vilasrao

ABSTRACT

Virosomes are reconstituted viral envelopes that can serve as vehicles for cellular delivery of macromolecules. The prospect of drug delivery and targeting using virosomes is an interesting field of research and development. Because virosomes are biocompatible, biodegradable, nontoxic and non-autoimmunogenic.Attempts have been made to use them as vaccines or adjuvants as well as delivery systems for drugs, nucleic acids or genes for therapeutic purposes. Influenza virus is the most common virus of choice. The success of virosomal drug delivery depends on method used to prepare the encapsulated bioactive materials and incorporate them into the virosomes. Virosome technology could potentially be used to deliver peptides, nucleic acids or genes and drugs like antibiotics, anticancer agents, and steroids.This review articlesummarizes themethod of preparation, administration, characterization, evaluation, and future aspects of virosomes.

Keywords: Virosomes, Influenza virus, Vaccine, Haemaggulatinin (HA), Neuraminidase (NA).