Abstract

SELF NANOEMULSION: ADVANCE FORM OF DRUG DELIVERY SYSTEM

Mr. Girish C. Soni, S.K. Prajapati, Nirvesh Chaudhri*

ABSTRACT

The main objective this study is to prepare and evaluate the self nanoemulsifying drug delivery (SNEDDS) system in order to achieve a better dissolution rate of a poorly water soluble drug. The aim of the present work was to prepare a novel self nanoemulsion drug delivery system (NE) to enhance the solubility. Lipid based self nanoemulsifying drug delivery system (SNEDDS) was explored to improve the oral bioavailability of a poorly water-soluble drug candidate, using spontaneous emulsification method. Nanoemulsions have ability to enhance the oral bioavailability of poorly water soluble or lipophilic drugs through selective lymphatic pathways. Self emulsifying drug delivery system has gained more attention due to enhanced oral bio-availability enabling reduction in dose, more consistent temporal profiles of drug absorption, selective targeting of drug(s) toward specific absorption window in GIT. SEDDS are liquid to semisolid in nature, but it has drawbacks as formulation development, quality control, stability etc. These liquid SEDDS can be converted into solid dosage form without affecting drug release property.

Keywords: Lipid, GIT, Nanoemulsions