Abstract

ANALGESIC POTENTIAL AND PHYTOCHEMICAL SCREENING OF LABLAB PURPUREUS AERIAL PARTS

Jajiratul Jannat Proma, Mohammad Omar Faruque, Shahnaz Rahman, A.B.M. Anwarul Bashar, Mohammed Rahmatullah*

ABSTRACT

Background. Lablab purpureus, also known as the hyacinth bean is cultivated throughout Bangladesh for its edible beans. It was of interest to phytochemically screen and evaluate the analgesic properties of the aerial parts. Methods. Analgesic activity was determined by observed decreases in abdominal constrictions (writhings) in intraperitoneally administered acetic acid-induced pain model in mice. Phytochemical screening was done through standard methods. Results. In analgesic activity tests, the extract at doses of 50, 100, 200 and 400 mg per kg body weight reduced the number of abdominal constrictions by 23.1, 34.6, 42.3, and 61.5%, respectively. A standard pain relieving (analgesic) drug, aspirin, reduced the number of writhings by 38.5%, when administered at a dose of 200 mg per kg body weight. Conclusion. Analgesic activity has not previously been reported for Lablab purpureus aerial parts. The aerial parts can be beneficial for alleviating pain.

Keywords: Lablab purpureus, analgesic, Fabaceae, hyacinth bean.