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Abstract

IN VIVO ANTIOXIDANT AND ANTIHYPERGLYCAEMIC PROPERTIES OF AQUEOUS EXTRACT OF A HERBAL COCKTAIL

1Ogugua V N, 2Egba S I٭, and 1Adoga J E.

1Department of Biochemistry, University of Nigeria, Nsukka, Enugu State, Nigeria.
2Department of Biochemistry, Michael Okpara University of Agriculture, Umudike, Abia State, Nigeria.

ABSTRACT

The antioxidant and antihyperglycaemic effect of herbal cocktail namely: vernonia amygdalina, Gongronema latifolium, Allium sativium, Ocimum gratissmun and Aloe barbadensis was studied on alloxan induced Diabetic Rat. Twenty (20) albino wistar Rats were equally divided into five groups. Groups 1 and 2 served as normal and untreated Diabetic controls. Test groups 3, 4 and 5 were treated with 10mg/kg glibenclamide, 200mg and 400mg/kg of extract for 28 days. The result showed a dose dependant significant increase (P<0.05) in serum concentrations of vitamin C, glutathione and catalase activity in test groups when compared to untreated diabetic control. Similarly, the extract significantly reduced (P<0.05) glucose concentration of diabetic rats at both concentrations when compared to untreated diabetic Rats. The results confirmed the already established use of these plants in traditional medicine and equally established their useful synergistic effect in reducing blood sugar and in relieving oxidant stress.

Keywords: Antioxidant, catalase, glutathione, alloxan, antihyperglycaemia, glibenclamide.


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