Abstract

PRONIOSOMES FORMULATION AND EVALUATION BY SLURRY METHOD AS AN EMERGING PROVESICULAR DRUG CARRIER IN NDDS.

Santosh Kumar*, Rishikesh Gupta , Dr. S. K. Prajapati, Nikhil Gupta, Snigdha Pattnaik and Ashu Agrawal

ABSTRACT

The purpose of this research was to formulate and evaluate Gliclazide loaded maltodextrin based proniosomes for oral route administration. For stabilizing niosomal drug delivery system without affecting its properties of merits have resulted in the development of the promising drug carrier “Proniosomes”. Proniosomes is a dry formulation using suitable carrier coated with non-ionic surfactants and can be converted into niosomes immediately before use by hydration. These proniosome-derived niosomes are as good as or even better than conventional niosomes.Gliclazide loaded Maltodextrin , Mannitol and Sorbitol based proniosomes were prepared by slurry method with different surfactant to cholesterol ratio.The proniosome formulations were evaluated for FT-IR study, angle of repose and scanning electron microscopy and other evaluation parametrs. The niosomal suspensions were further evaluated for entrapment efficiency, In-vitro release study, Kinetic data analysis, Stability study. The result from SEM analyses has confirmed the coating of surfactant on the surface of carrier. The formulation based maltodextrin showed higher entrapment efficiency of 82.64 ± 1.25 and in-vitro release of 98% at the end of 24hr was found to be best among the various formulations. The proniosome formulations were evaluated for FT-IR study, angle of repose and scanning electron microscopy and the result showed that the maltodextrin based formulation was best suited. Release was best explained by the zero order kinetics. Kinetic analysis shows that the drug release follows super case II transport diffusion.Maltodextrin based Proniosome formulation has showed appropriate stability for 90 days when compared with other carriers reconstituted niosomes by storing the formulation at refrigerator condition.

Keywords: Gliclazide, Proniosomes, Maltodextrin, Mannitol, Sorbitol, Span-40, FT-IR, and SEM.