Abstract

DELINEATE RELATION OF BIOCHEMICAL MARKER URIC ACID (UA) IN TYPE II DIABETES AND TO FIND THE GENETIC BACKGROUND OF THIS BIOMARKER

S.N. Malviya*, RamdasMalakar, Shikha jain, Manpreet Kaur, Afroze Ahmed, and C.B.S. Dangi

ABSTRACT

Diabetes mellitus is a group of metabolic diseases characterized by uncontrolled blood glucose levels. The prevalence of diabetes mellitus in World population is increasing in epidemic. Diabetes (Type I (IDDM) and Type II (NIDDM) are multi factorial disease. Type II is caused by oligo and polygenic genetic factors as well as non-genetic factors (environmental) that result from a lack of balance between the energy intake and output and other life style related factors. Diabetes is one of the major causes of premature mortality, stroke, cardiovascular disease, peripheral vascular disease, congenital malformations as well as long- and short-term disability. The correlation is present in serum uric acid level and age of the diabetic subject which shows that elevation in serum uric acid values as age of the patient increases. Serum UA levels were increased in Type II diabetic patients and this phenomenon seemed to be more profound in male diabetic patients as compare to female. An estrogen promotes uric acid excretion thus it may be the reason that hyperuricemia in men and increased levels of serum uric acid in postmenopausal women was observed. The levels of fasting blood glucose and HbA1c was found to be increased in both types of diabetes mellitus which alerts great concern globally that the patient must take antidiabetic medications along with proper balanced diet and must do mild exercise regularly. Together, these facts have galvanized international efforts to research the causes of type 2 diabetes mellitus and to develop effective preventive and therapeutic tools and strategies for managing the disease

Keywords: Uric acid, Type-II Diabetes, biomarker, HBA1c