Abstract

EVALUATION OF ANTI-DIABETIC ACTIVITY OF 2, 4, 6-TRIHYDROXY PHENYL PROPIONATE ISOLATED FROM TRIUMFETTA ROTUNDIFOLIA (LAM). IN STREPTOZOTOCIN INDUCED ON WISTAR RATS

R. Sanilkumar* and A.Kottai Muthu

ABSTRACT

The anti-diabetic activity of 2, 4, 6 - Trihydroxy phenyl propionate isolated from Triumfetta rotundifolia (Lam.) in streptozotocin induced diabetic rats was investigated in the present study. Streptozotocin was used to induce diabetes mellitus. The anti-diabetic potential was assessed by determining oral glucose tolerance, fasting blood glucose, urine glucose, liver glycogen content, serum lipid profile, change in body weight and histopathology studies. 2, 4, 6-Trihydroxy phenyl propionate isolated from Triumfetta rotundifolia was administered to normal and experimental diabetic rats for 15 days. Significant (p<0.001) reduction in fasting blood glucose levels was observed in the 2, 4, 6-Trihydroxy phenyl propionate is treated diabetic animals from day 7 onwards. In oral glucose tolerance test, reduction in fasting blood glucose a level was noted after 60 min of extract administration. After 15 days of treatment with extracts the maximum reduction in fasting blood glucose (53.87%) was observed in diabetic rats treated with 2, 4, 6-Trihydroxy phenyl propionate isolated from Triumfetta rotundifolia (50mg/kg/body wt). Serum lipid levels reversed towards near normal and the loss of body weight was controlled in treated rats as compared to diabetic control. The extract treatment also showed a significant increase in the liver glycogen content and gradual decrease in level of urine sugar level of sugar level. Microscopically examined pancreas section of rats treated with 50mg/kg isolated compound showed normal architecture of pancreas. The results demonstrate that whole plant of 2, 4, 6-Trihydroxy phenyl propionate isolated from Triumfetta rotundifolia possesses significant anti-diabetic activity.

Keywords: Triumfetta rotundifolia, 2, 4, 6-Trihydroxy phenyl propionate, Streptozotocin, Diabetes.