Abstract

IN SILICO STUDIES FOR UNDERSTANDING THE ROLE OF LOVASTATIN-ONE DRUG MANY APPLICATIONS

Kudaravalli Sreedevi*, Dr.J.Venkateswara Rao, Dr. M.Lakshmi Narasu

ABSTRACT

Lovastatin is a drug with host of biomedical applications. It is usually produced by the filamentous fungi as a secondary metabolite. Aspergillus terrus is widely studied for its production. The objective of the present article is to establish the biomedical role of lovastatin against the protein drug targets for Alzheimer‟s disease, cholesterol synthesis, obesity and cancer. In this endeavor, the experiment proceeds in silico. The dock results were promising and confirm the lovastatin‟s role for curing the diseases. It was observed that lovastatin proved to be excellent against cholesterol synthesis with the highest dock score of 52.242, followed by its action against obesity with 42.224. Nevertheless, lovastatin also establishes itself as a drug for Alzheimer‟s and cancer with the dock scores of 41.919 and 35.5 respectively.

Keywords: Lovastatin, cholesterol synthesis, Alzheimer?s disease, obesity, Cancer, Discovery studio.