Abstract

HYPROMELLOSE – A CHOICE OF POLYMER IN EXTENDED RELEASE TABLET FORMULATION

Dipti Phadtare*, Ganesh Phadtare , Nilesh B*, Mahendra Asawat*

ABSTRACT

Hydroxypropylmethylcellulose (HPMC) also know as hypromellose, is largely in used cellulose ether in the development of hydrophilic matrices. Hypromellose provides the release of a drug in a controlled manner, effectively increasing the duration of release of a drug to prolong its therapeutic effect. This review provides a current insight into hypromellose and its applicability to hydrophilic matrices in order to highlight the basic parameters that affect its performance. Topics covered include the chemical, thermal and mechanical properties of hypromellose, hydration of the polymer matrices, the mechanism of drug release and the various models used to predict the kinetics and mechanism of drug release from the HPMC matrices. This review also provides the maximum potency of hypromellose used in various dosage form and current patent status review of hypromellose as a release controlling polymer in extended release matrix systems.

Keywords: Hydrophilic matrix; HPMC; release mechanism; mathematical models; patent