Abstract

INVESTIGATION OF AQUEOUS EXTRACT OF ROOTS OF CANTHIUM DICOCCUM IN STREPTOMYCIN INDUCED NEPHROTOXICITY IN ANIMAL MODEL

Malothu Nagulu*, T.Mangilal, R. Naga Kishore, G.Abhinayani and N.Sravya

ABSTRACT

The present study aimed to evaluate the protective effect of aqueous extract of canthium dicoccum against Streptomycin-induced nephrotoxocity in rats. Streptomycin -administered rats (control group) had encountered acute kidney dysfunction as evidenced by elevation in serum urea and creatinine. Treatment of aqueous extract of C.dicoccum at the dose level of 100 and 200mg/kg for 14 days significantly lowered the serum level of creatinine, urea and uric acid when compared with the control group. The statistical significance of the nephroprotective activity of C. dicoccum treated group and the Cystone treated group were compared against control were found almost equal as both groups gained significance (P<0.05) against the control group in most of the parameters including serum urea and creatinine. The results of our study suggest that the C. dicoccum possesses nephroprotective potential on the dose dependant manner and substantiate the therapeutic utility in renal injury. Extensive further research is needed to elucidate the exact mechanism of nephroprotective action of the C. dicoccum.

Keywords: Streptomycin, Canthium dicoccum, Cystone, Nephroprotective.