Abstract

INVESTIGATION OF ANTI OBESITY ACTIVITY OF ALCOHOLIC EXTRACT OF ROOTS OF CARICA PAPAYA ON OBESITY INDUCED ANIMAL MODEL

Jatoth Manjula*, T.Mangilal, R. Naga Kishore,N.Anjaneyulu, M. Naga Ganesh, G.Abhinayani And N.Sravya

ABSTRACT

The present study is to evaluate the anti-obesity activity of alcoholic extract of roots of Carica Papaya. Phytochemical screening of crude extract reveals the presence of carbohydrates, proteins, flavonoids, saponins, fixed oils, glycosides and steroids. Hence the presence of bioactive constituents was aimed to explore the anti obesity activity of roots extracts in Atherogenic Diet (AD) induced obesity model in experimental animals i.e. mice. Standard reference Orlistat (10 mg/kg) produced a significant (P<0.05) anti obesity activity in AD induced obesity in mice. Plant extracts at both doses i.e., 100 mg/kg and 200 mg/kg exhibited a significant (P<0.05) antiobesity activity by reducing the body weight, food intake, organ and fat pads weight and serum GLU, CHO, TRG, LDL and VLDL cholesterol levels with an increased HDL levels in AD induced obesity models in mice.

Keywords: Carica Papaya, Atherogenic Diet, Obesity, Orlistat.