Abstract

ASSESSMENT OF PROTECTIVE EFFECTS OF POLYPHENOL-RICH FRACTIONS FROM TRICHILIA EMETICA (MELIACEAE) ON SOME INCATORS OF LIVER AND KIDNEYS FUNCTIONS IN EXPERIMENTAL MODEL

Kiessoun Konaté*, Kassi Yomalan, Oksana Sytar, Marian Brestic

ABSTRACT

The present study was conducted to evaluate the hepato and nephroprotective effects of polyphenol-rich fractions from Trichilia emetica in rodents. Animals received by gavage 75, 100 and 200 mg/kg body weight of fraction daily for a period of 28 days. Control groups received alcohol 35% and water. In vivo administration of 35% ethanol for a period of 28 days in rats showed an activity of liver marker enzymes (AST, ALT, ALP and GGT), triglycerides, total cholesterol, total bilirubin and direct bilirubin and nephrotoxicity biomarkers (total proteins, serum albumin, urea, uric acid and creatinine) in serum compared with rats which received water (control water). However, administration of 35% ethanol along with bioactive fraction decreased the activities of liver and kidneys biomarkers enzyme in serum (p<0.05 or p<0.01) comparatively to the control water groups. This study revealed that Trichilia emetica presents hepato and nephroprotective potentials and this plant could be exploited in the treatment of liver and kidneys diseases

Keywords: Trichilia emetica, polyphenol-rich fractions, liver and kidneys functions, rodents.