WJPPS Citation

Login

Search

News & Updation

  • Updated Version
  • WJPPS introducing updated version of OSTS (online submission and tracking system), which have dedicated control panel for both author and reviewer. Using this control panel author can submit manuscript
  • Call for Paper
    • WJPPS  Invited to submit your valuable manuscripts for Coming Issue.
  • Journal web site support Internet Explorer, Google Chrome, Mozilla Firefox, Opera, Saffari for easy download of article without any trouble.
  •  
  • New Impact Factor
  • WJPPS Impact Factor has been Increased to 8.025 for Year 2024.

  • WJPPS: MARCH ISSUE PUBLISHED
  • March Issue has been successfully launched on 1 March 2024.

  • ICV
  • WJPPS Rank with Index Copernicus Value 84.65 due to high reputation at International Level

  • Scope Indexed
  • WJPPS is indexed in Scope Database based on the recommendation of the Content Selection Committee (CSC).

Abstract

MICROWAVE ASSISTED SYNTHESIS AND IN VITRO ANTIMALARIAL SCREENING OF NOVEL PYRIMIDINE DERIVATIVES

Dayena J. Christian, Manoj N. Bhoi, Mayuri A. Borad, Dhanji P.Rajani, SmitaD.Rajani, Hitesh D. Patel*

ABSTRACT

This research article mainly emphases on recent endeavors in the field of heterocyclic compounds. Pyrimidines have extensively explored in medicinal chemistry because of their wide range of biological activities. Keeping this in view, we have synthesized some novel pyrimidine derivatives from novel chalcones by the condensation reaction with guanidine hydrochloride/thiourea. All these synthesized compounds were characterized by IR, 1H NMR, Mass spectral dataandelemental analysis. These compounds were also screened for In Vitroanti-malarial activity. Among all evaluated compounds, the molecule 5cand 7c exhibit the most pronounced excellent anti-malarial activity IC50Value (μg/mL) 0.028, 0.078 respectively.

Keywords: Anti-malarial agent, Amino-pyrimidine, Chalcones,Microwave assistant reaction, Plasmoduim falciparum, Pyrimidines.


[Download Article]     [Download Certifiate]

Call for Paper

World Journal of Pharmacy and Pharmaceutical Sciences (WJPPS)
Read More

Online Submission

World Journal of Pharmacy and Pharmaceutical Sciences (WJPPS)
Read More

Email & SMS Alert

World Journal of Pharmacy and Pharmaceutical Sciences (WJPPS)
Read More