Abstract

EVALUATION OF ANTIHYPERLIPIDEMIC ACTIVITY OF METHANOLIC EXTRACT OF LEAVES OF PRUNUS PERSICA

Usharani Chatragadda*, Sumalatha Gindi, Vimochana Bowjanku

ABSTRACT

The aim of the present study was to evaluate the Antihyperlipedemic activity of methanolic extracts of leaves of Prunus persica using high fat diet-induced hyperlipidemia and TritonX-100 induced hyperlipidemia models in Wistar albino rats. Hyperlipidemia is a disorder of lipid metabolism manifested by elevation of plasma concentrations of the various lipid and lipoprotein fractions, which is the key risk factor for cardiovascular disorders (CVD). Prunus persica extract was administered at different dose of 100mg/kg, 200mg/kg, 400mg/kg to hyperlipidemic rats. Atorvastatin is used as reference standard. The statistical analysis were carried out using one way ANOVA followed by Dunnet’s multiple comparison test. The serumTotal cholesterol, Triglyceride, HDL, VLDL , LDL levels and atherogenic index were analyzed. There is also significant improvement in atherogenic index in 400mg/kg extract treated animals. Methanolic leaf extract of prunu persica exhibited significant (p<0.01) effect in reducing the serum cholesterol , lipid levels and atherogenic index. The present study clearly demonstrated the antihyperlipedemic activity of Prunus persica supporting the traditional claim

Keywords: Hyperlipidemia, Prunus persica, high fat diet, triton x 100, atorvastatin.