WJPPS Citation

Login

Search

News & Updation

  • Updated Version
  • WJPPS introducing updated version of OSTS (online submission and tracking system), which have dedicated control panel for both author and reviewer. Using this control panel author can submit manuscript
  • Call for Paper
    • WJPPS  Invited to submit your valuable manuscripts for Coming Issue.
  • Journal web site support Internet Explorer, Google Chrome, Mozilla Firefox, Opera, Saffari for easy download of article without any trouble.
  •  
  • New Impact Factor
  • WJPPS Impact Factor has been Increased to 8.025 for Year 2024.

  • WJPPS: MARCH ISSUE PUBLISHED
  • March Issue has been successfully launched on 1 March 2024.

  • ICV
  • WJPPS Rank with Index Copernicus Value 84.65 due to high reputation at International Level

  • Scope Indexed
  • WJPPS is indexed in Scope Database based on the recommendation of the Content Selection Committee (CSC).

Abstract

PREPARATION & EVALUATION OF MOUTH DISSOLVING FILM OF PANTOPRAZOLE SODIUM

Bhupendra Nath Dwivedy*, Prashant Dabral, Rajeev Kumar

ABSTRACT

New drug delivery system for the oral delivery of drug, was developed based on the technology of the transdermal patch. It consists of a very thin oral strip which releases the active ingredient immediately after uptake into the oral cavity. The technique involved in the preparation of mouth dissolving film was solvent casting method in which aqueous solution I (polymer & glycerine) and aqueous solution II (drug, Mannitol, Vanilla flavor, and saccharine) was prepared in specific proportion in distilled water. Both solution I & II were mixed & stir for 1 hour & kept for 1 hour to remove all air bubbles. Then the mixture solution was poured into petridish & it was dried in oven at 40-50 0C for 7- 8 hours then film was removed from petridish and cut according to Size (square film: 2cm length, 2cm width). Ingredients Used In Mouth Dissolving Film Preparations: Variable Ingredients: - PVA, HPMC, HPC and Glycerin. Pantoprazole is a highly potent proton pump inhibitor, chemically a weak base, it concentrates under the acidic conditions of parietal cell secretory canaliculi where it is converted to a cationic cyclic sulfonamide by rearrangement. This activated molecule binds to two site of hydrogen/potassium ATPase (proton pump) in the gastric parietal cells, inactivating the system, which in turn blocks the final step of secretion of hydrochloric acid by these cells, producing a long lasting effect

Keywords: Pantoprazole Sodium, Mouth Dissolving Film, OralFilm, Oral Strip.


[Download Article]     [Download Certifiate]

Call for Paper

World Journal of Pharmacy and Pharmaceutical Sciences (WJPPS)
Read More

Online Submission

World Journal of Pharmacy and Pharmaceutical Sciences (WJPPS)
Read More

Email & SMS Alert

World Journal of Pharmacy and Pharmaceutical Sciences (WJPPS)
Read More