Abstract

DEVELOPMENT AND EVALUATION OF PARENTERAL DOSAGE FORM FOR ANTICANCER ACTIVITY

Sakshi Dhall, Komal Goswami, Gaurav Khurana, Rakesh Kumar Marwaha, PritiMehndiratta, Minakshi Gupta*

ABSTRACT

The present work described the development of stabilized parenteral formulation of an anthracycline antineoplastic agent which is used in treatment of bladder cancer. A different type of treatment is available for bladder cancer. One of them is intravesical therapy which is most safe and effective therapy. The parenteral formulation containing 40 mg/ml drug was prepared by using 50% dehydrated alcohol and 50% Polyoxyl castor oil as excipients. The formulation was evaluated for chemical analysis and result was found to be very good and it matches with innovator profile as well. Characterisation of formulation was done by HPLC method.

Keywords: Anthracycline antineoplastic agent, Bladder cancer, Intravesical therapy, Polyoxyl castor oil.