WJPPS Citation

Login

Search

News & Updation

  • Updated Version
  • WJPPS introducing updated version of OSTS (online submission and tracking system), which have dedicated control panel for both author and reviewer. Using this control panel author can submit manuscript
  • Call for Paper
    • WJPPS  Invited to submit your valuable manuscripts for Coming Issue.
  • Journal web site support Internet Explorer, Google Chrome, Mozilla Firefox, Opera, Saffari for easy download of article without any trouble.
  •  
  • New Impact Factor
  • WJPPS Impact Factor has been Increased to 8.025 for Year 2024.

  • WJPPS: MARCH ISSUE PUBLISHED
  • March Issue has been successfully launched on 1 March 2024.

  • ICV
  • WJPPS Rank with Index Copernicus Value 84.65 due to high reputation at International Level

  • Scope Indexed
  • WJPPS is indexed in Scope Database based on the recommendation of the Content Selection Committee (CSC).

Abstract

SYNTHESIS, ANTIMICROBIAL, ANTITUBERCULAR AND CYTOTOXIC STUDIES OF SOME PYRIMIDINE DERIVATIVES DERIVED FROM CHALCONES

*K. Ishwar Bhat, Abhishek Kumar, Pankaj Kumar & Riyaz E.K

ABSTRACT

A series of novel 6-(substituted phenyl)-4-(nitrophenyl) pyrimidin-2-ol (RPY1-RPY6) have been synthesized upon refluxing with 3-(4- nitrophenyl)-1-phenyl substituted prop-2-en-1-one in presence of urea and glacial acetic acid. 3-(4-nitrophenyl)-1-phenyl substituted prop-2- en-1-one (RC1-RC6) were prepared by reaction with 4- nitrobenzaldehyde and substituted acetophenones in presence of NaOH. The structures of the final synthesized compounds were confirmed by IR, 1H NMR and mass spectra. All the new compounds were screened for their in-vitro antimicrobial, antitubercular and cytotoxic activities. Most of the compounds have exhibited promising antibacterial, antifungal, antitubercular and cytotoxic activities.

Keywords: Chalcones, pyrimidines, antibacterial activity, antifungal activity, antitubercular activity, cytotoxic activity.


[Download Article]     [Download Certifiate]

Call for Paper

World Journal of Pharmacy and Pharmaceutical Sciences (WJPPS)
Read More

Online Submission

World Journal of Pharmacy and Pharmaceutical Sciences (WJPPS)
Read More

Email & SMS Alert

World Journal of Pharmacy and Pharmaceutical Sciences (WJPPS)
Read More