Abstract

THE EFFECTIVE STUDY OF AQUEOUS EXTRACT OF CROCUS SATIVUS LINN. IN CHEMICAL INDUCED CONVULSANTS IN RATS.

Sunanda B,P.V*, Rammohan.B, Amitabh kumar, Kudagi BL

ABSTRACT

To evaluate the anti-convulsion activity of Crocus sativus linn. aqueous extract in chemical induced epilepsy models. To compare the anti convulsant activity of crocus sativus linn. With sodium valporate .After obtaining Institutional Ethical Committee approval, Wistar albino rats (150-200g) of either sex were randomly divided into 5 groups of 6 animals each. Dried powder ofcrocus sativus linn. was boiled with distilled water, cooled, filtered, placed on hotplate for complete evaporation, finally weighed and stored. All the groups are injected with Pentylenetetrazole (PTZ) of dose 700mg/kg i.v .The control group, test group and standard drugs group received saline, crocus sativus linn. extract (200,400 & 800 mg/kg), sodium valporate (300 mg/kg) respectively by oral feeding. The anti-convulsent effect was assessed by induced PTZ in rats. In PTZ induced epilepsy models It implies that saffron 400mg/kg (groupIV) and 800mg/kg (groupV) significantly (p<0.001) delays the onset of PTZ induced convulsions and significantly (p<0.001) decreased the decreased the duration of clonic convulsions compared to that of control. The current study demonstrates statistically significantanti-convulsant activity of crocus sativus linn.

Keywords: Crocus sativus Linn., anti-convulsant, PTZ , sodium valproate.