Abstract

TASTE MASKED BEADS OF ONDANSETRON HYDROCHLORIDE USING NATURAL POLYMER XYLOGLUCAN

Mangesh .R. Bhalekar*, Ashwini R. Madgulkar, Rahul R. Padalkar, Dipul B. Manwar

ABSTRACT

This work was aimed at masking the bitter taste of ondansetron HClusing Ionotropic gelation technique. Ondansetron HCl is 5HT3 receptorantagonist commonly used in treatment of emesis. Oral adminstrationof ondansetron HCl faces major problem due to its bitter taste. In thiswork taste masking was done by formulating tasteless beads ofondansetron HCl using varied concentration of xyloglucan polymer byionic orifice gelation technique. beads were evaluated for variousparameter like drug content, particle size, entrapment efficiency, invitro taste evaluation and drug release. Use of 3% polymerconcentration shows 98 % practical yield of beads having 90.60 %entrapment efficiency, particle size 630 μm. SEM study reveals spherical shape with roughsurface of beads, in vitro taste evaluation of beads shows that satisfactory taste masking wasachieved. Drug release from beads was found to be 84.34 % within 20 min. These beads werecompressed into fast disintegrating tablet which rapidly disintegrated in oral cavity.Crospovidone was used as a superdisintegrant. 4 batches of tablets were prepared by varyingconcentration of crospovidone from 2-5 %.tablets were subsequently evaluated for variouspharmacopoeial tests, drug release and disintegration time. The results were found to besatisfactory.

Keywords: Ondansetron HCl, xyloglucan, Taste masking, beads